Cambridge Healthtech Institute’s 6th Annual

Cell Line Development

New Technologies, Big Data Solutions, and Best Practices for Engineering Robust Cell Lines

20-21 March 2024

As the biopharma field becomes increasingly more complex, the engineering of cell lines remains a foundation step for developing biologic drugs. This foundation applies emerging research and breakthrough strategies to achieve cell lines that accomplish project goals quickly and inexpensively. In support of these goals, the 6^th Annual Cell Line Development conference offers an expert faculty sharing strategies and best practices on cell engineering, engineering for emerging modalities, new technologies, and the integration of modeling and machine learning into this stage of upstream processing.

Coverage will include, but is not limited to:

Cell Engineering

Engineering intracellular transport
Genome-scale modeling to guide cell line performance improvement
Next-generation technologies for cell line engineering and gene editing; resolving IP constraints

Cell Line Development for Novel Modalities

Cytokine fusions
Engineering producer cell lines for viral vectors
Synthetic biology to engineer cell and gene therapy payloads

Emerging Technologies

Novel alternate expression systems
Strategies and technologies to expand the use of non-clonal pools
Transcriptomic analysis to characterise cell behavior

Modeling and Machine Learning in Cell Line Development

Machine learning for early identification of promising clones
Modeling metabolic pathways
Systems biology models for CLD in complex multispecific formats

Problems and Solutions

Considerations and strategies for moving to alternative cell lines
Modulating glycosylation
Resolving chromosomal instability

The deadline for priority consideration is Friday 22 September.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: