Cambridge Healthtech Institute’s 8th Annual
Cell Culture and Cell Line Engineering: Parts 1/2
Part 1: 18-19 March 2025, Part 2: 19-20 March 2025
Cambridge Healthtech Institute's 8th Annual Cell Culture and Cell Line Engineering conference explores cutting-edge technologies and strategies for enhancing cell cultivation and engineering processes in biopharmaceutical development. The program covers advancements in targeted integration, metabolic design, and emerging technologies for cell line development, including high-throughput screening and novel gene editing applications. A significant focus is placed on machine learning applications in upstream processing and cell line engineering, addressing areas such as chemometrics, process optimisation, and cell line performance prediction. The conference also delves into sustainability improvements, perfusion bioreactor optimisation, and upstream processing solutions for emerging modalities, offering insights into the latest innovations driving efficiency and productivity in biotherapeutic production.
Coverage will include, but is not limited to:
Advances in Targeted Integration and Metabolic Design
- Site-specific integration
- Synthetic biology for designing novel metabolic pathways in production cell lines
- Transposon technologies
Emerging Technologies for CLD
- High-throughput screening and selection of producer cell lines
- New applications of gene editing
- Synthetic biology approaches for designing novel metabolic pathways in production cell lines
ML Applications for Chemometrics in Upstream Processing
- Anomaly detection
- Development and training of mechanistic models
- Exploration and visualisation of high-dimensional process data
- Process optimisation
- Real-time prediction of key process parameters and quality attributes
- Synthetic biology approaches for designing novel metabolic pathways in production cell lines
ML Applications in Cell Line Engineering and CLD
- Cell line performance prediction
- ML-guided plasmid design
- Recombinant construct design
- Using historical data to predict cell line manufacturability
Sustainability Improvements
- High-cell-density culture techniques
- Improving bioreactor oxygen and mass transfer capabilities
- Improving metabolic efficiency of cell lines
- Media optimisation
Optimising Perfusion Bioreactors
- Continuous perfusion
- Emerging inline sensor and noninvasive measurement technologies for monitoring KPPs
- Strategies for maintaining cell viability and productivity in long-term perfusion cultures
Upstream Processing for Emerging Modalities
- Process intensification for high-density AAV production
- Product-specific cell engineering
- Technologies to increase the scale of allogeneic stem cell production and ensure consistent product quality
The deadline for priority consideration is Friday 13 September.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: