Cambridge Healthtech Institute’s Inaugural
Next-Generation Analytical Methods
19-20 March 2025
Biotherapeutic development is now entering an interesting stage, where a progression of increasingly complex therapeutic modalities and precision manufacturing approaches is demanding more capabilities from the analytical tools used throughout development. CHI's inaugural Next-Generation Analytical Methods conference offers protein scientists and analytical specialists the opportunity to explore the latest technologies and methods for problem-solving in this dynamic field. Two full days of presentations will explore emerging technologies, the needs for new modality-specific solutions, the evolution of core analytical methods, new applications of spectroscopic methods, and exciting advances in process analytics. The formal conference presentations will be augmented by moderated small-group discussions, scientific posters, and abundant opportunities for networking.
Coverage will include, but is not limited to:
Analytical Methods for Formulation Development
- MDS for stability prediction and analysis of excipients
- Methods to support formulation challenges of novel modalities
- New strategies for analysis of high-concentration protein formulations
Emerging Methods to Support Complex Biotherapeutic Modalities
- Characterisation for complex bi and multispecifics
- Method selection and best practices for AAV characterisation
- New bioassays for potency and immunogenicity
- Understanding the mechanisms of ADC degradation and free drug
New MS Applications and Technologies
- Intact mass analysis to eliminate chemical-based release testing
- LC-MS for detection and characterisation of host-cell proteins
- Strategies for integrating of MS into platformed methods and workflows
New Technologies to Support the Implementation of ML/AI in Analytical Development
- Automated data handling
- Digitised ELNs
- Models to support characterisation and CQA identification for viral vectors
Problems and Solutions
- Can clinical data be used for CMC specification setting?
- Sustainability initiatives in bioprocess analytics
- Technologies to enable low-concentration or ultra-low volume analyses
The deadline for priority consideration is Friday 13 September
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: